CASE REPORT: PARADOXICAL ACRODERMATITIS OF HALLOPEAU-LIKE ERUPTION FOLLOWING ANTI-IL-17 THERAPY [VERSION 1; PEER REVIEW: 2 APPROVED]

Case Report: Paradoxical acrodermatitis of Hallopeau-like eruption following anti-IL-17 therapy [version 1; peer review: 2 approved]

Psoriasis is a chronic immune-mediated inflammatory disease.Up to 40% of patients with psoriasis may develop psoriatic arthritis.Currently, interleukin (IL)-17/IL-23 pathways are identified as key factors in the immunopathogenesis of both conditions.Here we describe the case of a patient who developed psoriasiform skin lesions 10 months after the i

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Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways

DNA methylation is a frequent epigenetic mechanism that participates in transcriptional repression.Variations in DNA methylation with respect to gene expression are constant, and, for unknown reasons, some genes with highly methylated promoters are sometimes overexpressed.In this study we have analyzed the expression and methylation patterns of tho

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